Version: 8.0.0Date: Tue Jan 28 2025
Gene
CCND2
- Species
- Homo sapiens
- Symbol
- CCND2
- Name
- cyclin D2
- Synonyms
- G1/S-specific cyclin D2
- G1/S-specific cyclin-D2
- Biotype
- protein coding gene
- Automated Description
- Enables cyclin-dependent protein serine/threonine kinase activator activity and protein kinase binding activity. Involved in several processes, including G1/S transition of mitotic cell cycle; negative regulation of apoptotic process; and positive regulation of cell cycle. Located in chromatin; cytosol; and nucleus. Part of cyclin D2-CDK4 complex. Implicated in several diseases, including breast cancer (multiple); carcinoma (multiple); ductal carcinoma in situ; hepatitis B; and liver cancer (multiple). Biomarker of several diseases, including colon adenoma; gastrointestinal system cancer (multiple); germ cell cancer (multiple); granulosa cell tumor; and hepatitis B.
- RGD Description
- The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with CDK4 or CDK6 and functions as a regulatory subunit of the complex, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. Mutations in this gene are associated with megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 3 (MPPH3). [provided by RefSeq, Sep 2014]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10177
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr12:4269771...4305353 + (35.58 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.