Enables protein phosphatase regulator activity. Involved in establishment of endothelial barrier; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in several cellular components, including nuclear speck; perinuclear region of cytoplasm; and plasma membrane.
RGD Description
The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]