Gene

PPP1R16B

Species
Homo sapiens
Symbol
PPP1R16B
Name
protein phosphatase 1 regulatory subunit 16B
Synonyms
  • ANKRD4
  • ankyrin repeat domain protein 4
Biotype
protein coding gene
Automated Description
Enables protein phosphatase regulator activity. Involved in establishment of endothelial barrier; positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis; and regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Located in several cellular components, including nuclear speck; perinuclear region of cytoplasm; and plasma membrane.
RGD Description
The protein encoded by this gene is membrane-associated and contains five ankyrin repeats, a protein phosphatase-1-interacting domain, and a carboxy-terminal CAAX box domain. Synthesis of the encoded protein is inhibited by transforming growth factor beta-1. The protein may bind to the membrane through its CAAX box domain and may act as a signaling molecule through interaction with protein phosphatase-1. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24179
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
38.82M38.84M38.86M38.88M38.90M38.92M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions