Gene

PARD6A

Species
Homo sapiens
Symbol
PARD6A
Name
par-6 family cell polarity regulator alpha
Synonyms
  • PAR-6 alpha
  • par-6 partitioning defective 6 homolog alpha
Biotype
protein coding gene
Automated Description
Predicted to enable GTP-dependent protein binding activity and small GTPase binding activity. Involved in centrosome cycle; establishment or maintenance of epithelial cell apical/basal polarity; and positive regulation of protein localization to centrosome. Located in centriolar satellite. Part of PAR polarity complex.
RGD Description
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14102
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
67.6610M67.6612M67.6614M67.6616M67.6618M67.6620M67.6622M67.6624M67.6626M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions