Predicted to enable GTP-dependent protein binding activity and small GTPase binding activity. Involved in centrosome cycle; establishment or maintenance of epithelial cell apical/basal polarity; and positive regulation of protein localization to centrosome. Located in centriolar satellite. Part of PAR polarity complex.
RGD Description
This gene is a member of the PAR6 family and encodes a protein with a PSD95/Discs-large/ZO1 (PDZ) domain and a semi-Cdc42/Rac interactive binding (CRIB) domain. This cell membrane protein is involved in asymmetrical cell division and cell polarization processes as a member of a multi-protein complex. The protein also has a role in the epithelial-to-mesenchymal transition (EMT) that characterizes the invasive phenotype associated with metastatic carcinomas. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]