Gene

MLLT10

Species
Homo sapiens
Symbol
MLLT10
Name
MLLT10 histone lysine methyltransferase DOT1L cofactor
Synonyms
  • AF10
  • ALL-1 fused gene from chromosome 10
Biotype
protein coding gene
Automated Description
Enables histone binding activity and nucleosome binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. Part of protein-containing complex. Implicated in acute monocytic leukemia and acute myeloid leukemia.
RGD Description
This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13793
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusMllt1010 of 10YesYes  
Rattus norvegicusMllt1010 of 10YesYes  
Xenopus laevismllt10.L1 of 1YesYes           
Xenopus tropicalismllt105 of 9YesYes   
Danio reriomllt1010 of 10YesYes  
Drosophila melanogasterAlh5 of 9YesYes   
Caenorhabditis eleganszfp-17 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
MLLT61123153407 of 8  
BRPF32107133223 of 8  
BRPF1395835233 of 8  
BRD14105931213 of 8  
JADE1573237263 of 8  
JADE3676236243 of 8  
PHF14763438232 of 8  
JADE2859536253 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
Acute myeloid leukemia
Autosomal dominant inheritance
Typified by somatic mosaicism
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterHsap\MLLT10LZ.UAS
  • UAS
Drosophila melanogasterHsap\MLLT10UAS.Tag:HA
  • UASt
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
21.54M21.56M21.58M21.60M21.62M21.64M21.66M21.68M21.70M21.72M21.74M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

53 interactor genes based on 76 annotations
MLLT10 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
AFF1Homo sapiens
protein
  • affinity chromatography technology
PMID:21030982
protein
BRD3Homo sapiens
protein
  • proximity labelling technology
PMID:30554943
protein
CENPJHomo sapiens
protein
  • proximity labelling technology
PMID:26638075
protein
CTNNB1Homo sapiens
protein
  • affinity chromatography technology
PMID:20203130
protein
CTNNB1Homo sapiens
protein
  • pull down
PMID:21103407
protein
CTNNB1Homo sapiens
protein
  • pull down
PMID:21103407
protein
DAXXHomo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
DISC1Homo sapiens
protein
  • two hybrid
PMID:17043677
protein
DISC1Homo sapiens
protein
  • two hybrid fragment pooling approach
PMID:31413325
protein
DOT1LHomo sapiens
protein
  • affinity chromatography technology
PMID:15851025
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Genetic Interactions

No data available