Gene

TRIM6

Species
Homo sapiens
Symbol
TRIM6
Name
tripartite motif containing 6
Synonyms
  • RING finger protein 89
  • RING-type E3 ubiquitin transferase TRIM6
Biotype
protein coding gene
Automated Description
Enables several functions, including identical protein binding activity; protein tyrosine kinase binding activity; and ubiquitin protein ligase activity. Involved in several processes, including antiviral innate immune response; regulation of defense response; and regulation of macromolecule metabolic process. Is active in cytoplasm.
RGD Description
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, B-box type 1 and B-box type 2 domain, and a coiled-coil region. The protein localizes to the nucleus, but its specific function has not been identified. This gene is mapped to chromosome 11p15, where it resides within a TRIM gene cluster. Alternative splicing results in multiple transcript variants. A read-through transcript from this gene into the downstream TRIM34 gene has also been observed, which results in a fusion product from these neighboring family members. [provided by RefSeq, Oct 2010]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24103
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
5.598M5.600M5.602M5.604M5.606M5.608M5.610M5.612M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions