Version: 8.0.0Date: Tue Jan 28 2025
Gene
CD36
- Species
- Homo sapiens
- Symbol
- CD36
- Name
- CD36 molecule (CD36 blood group)
- Synonyms
- BDPLT10
- CD36 antigen (collagen type I receptor, thrombospondin receptor)
- Biotype
- protein coding gene
- Automated Description
- Enables several functions, including amyloid-beta binding activity; fatty acid transmembrane transporter activity; and low-density lipoprotein particle binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; fatty acid transport; and regulation of signal transduction. Located in several cellular components, including Golgi apparatus; cell surface; and membrane raft. Part of receptor complex. Implicated in several diseases, including blood platelet disease (multiple); hemolytic-uremic syndrome; osteoarthritis; pulmonary tuberculosis; and type 2 diabetes mellitus. Biomarker of several diseases, including autoimmune disease (multiple); myeloid neoplasm (multiple); myositis (multiple); rheumatic heart disease; and sickle cell anemia.
- RGD Description
- The protein encoded by this gene is the fourth major glycoprotein of the platelet surface and serves as a receptor for thrombospondin in platelets and various cell lines. Since thrombospondins are widely distributed proteins involved in a variety of adhesive processes, this protein may have important functions as a cell adhesion molecule. It binds to collagen, thrombospondin, anionic phospholipids and oxidized LDL. It directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes and it binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Mutations in this gene cause platelet glycoprotein deficiency. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2014]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR11923
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr7:80369575...80679277 + (309.70 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.