Gene

SRSF10

Species
Homo sapiens
Symbol
SRSF10
Name
serine and arginine rich splicing factor 10
Synonyms
  • 40 kDa SR-repressor protein
  • DKFZp686H0644
Biotype
protein coding gene
Automated Description
Enables RNA binding activity. Involved in mRNA splice site recognition and negative regulation of mRNA splicing, via spliceosome. Located in nuclear speck. Biomarker of macular degeneration.
RGD Description
This gene product is a member of the serine-arginine (SR) family of proteins, which are involved in constitutive and regulated RNA splicing. Members of this family are characterized by N-terminal RNP1 and RNP2 motifs, which are required for binding to RNA, and multiple C-terminal SR/RS repeats, which are important in mediating association with other cellular proteins. This protein interacts with the oncoprotein TLS, and abrogates the influence of TLS on adenovirus E1A pre-mRNA splicing. This gene has pseudogenes on chromosomes 4, 9, 14, 18, and 20. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR48034
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
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      Alleles and Variants

      Allele/Variant Symbol
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      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            23.966M23.968M23.970M23.972M23.974M23.976M23.978M23.980M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            SRSF10 molecule type
            Interactor gene
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            Interactor molecule type
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              Genetic Interactions

              SRSF10 role
              SRSF10 genetic perturbation
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