Version: 8.0.0Date: Tue Jan 28 2025
Gene
CD44
- Species
- Homo sapiens
- Symbol
- CD44
- Name
- CD44 molecule (IN blood group)
- Synonyms
- CD44 antigen
- CD44 molecule (Indian blood group)
- Biotype
- protein coding gene
- Automated Description
- Enables hyaluronic acid binding activity. Contributes to cytokine receptor activity. Involved in several processes, including hyaluronan catabolic process; positive regulation of cell-cell adhesion; and regulation of intracellular signal transduction. Located in several cellular components, including Golgi apparatus; apical plasma membrane; and lamellipodium membrane. Part of macrophage migration inhibitory factor receptor complex. Implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate cancer. Biomarker of carcinoma (multiple); invasive ductal carcinoma; leiomyomatosis; and urinary system cancer (multiple).
- RGD Description
- The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. [provided by RefSeq, Jul 2008]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10225
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr11:35138882...35232402 + (93.52 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.