Version: 8.0.0
Date: Tue Jan 28 2025
HCN4
Homo sapiensHGNC:16882
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

HCN4

Species
Homo sapiens
Symbol
HCN4
Name
hyperpolarization activated cyclic nucleotide gated potassium channel 4
Synonyms
  • BRGDA8
  • EIG18
Biotype
protein coding gene
Automated Description
Enables identical protein binding activity and monoatomic cation channel activity. Involved in several processes, including cellular response to cAMP; inorganic cation import across plasma membrane; and regulation of heart contraction. Located in perinuclear region of cytoplasm and plasma membrane. Part of HCN channel complex. Implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; idiopathic generalized epilepsy; and sick sinus syndrome.
RGD Description
This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR45689
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
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    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
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    Variant type
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
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        Models

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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          HCN4 molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
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            Genetic Interactions

            HCN4 role
            HCN4 genetic perturbation
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            Interactor genetic perturbation
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