Version: 8.0.0Date: Tue Jan 28 2025
Gene
DICER1
- Species
- Homo sapiens
- Symbol
- DICER1
- Name
- dicer 1, ribonuclease III
- Synonyms
- aviD
- DCR1
- Biotype
- protein coding gene
- Automated Description
- Enables RNA binding activity; protein domain specific binding activity; and ribonuclease III activity. Contributes to pre-miRNA binding activity. Involved in negative regulation of gene expression. Located in extracellular exosome and perinuclear region of cytoplasm. Part of RISC complex and RISC-loading complex. Implicated in DICER1 syndrome; gastrointestinal system cancer (multiple); multinodular goiter; nephroma; and pleuropulmonary blastoma. Biomarker of colorectal cancer; diffuse large B-cell lymphoma; and stomach cancer.
- RGD Description
- This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR14950
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Sequence Feature Viewer
- Genome location
- Chr14:95086228...95158010 - (71.78 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction