Gene

ORC6

Species
Homo sapiens
Symbol
ORC6
Name
origin recognition complex subunit 6
Synonyms
  • ORC6L
  • origin recognition complex, subunit 6 homolog-like
Biotype
protein coding gene
Automated Description
Predicted to enable DNA binding activity. Involved in DNA replication initiation. Located in fibrillar center and nucleoplasm. Part of nuclear origin of replication recognition complex. Implicated in Meier-Gorlin syndrome 3.
RGD Description
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13394
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
46.690M46.691M46.692M46.693M46.694M46.695M46.696M46.697M46.698M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions