Version: 8.0.0Date: Tue Jan 28 2025
Gene
CDK1
- Species
- Homo sapiens
- Symbol
- CDK1
- Name
- cyclin dependent kinase 1
- Synonyms
- CDC2
- CDC28A
- Biotype
- protein coding gene
- Automated Description
- Enables cyclin binding activity and protein kinase activity. Involved in several processes, including G2/M transition of mitotic cell cycle; protein phosphorylation; and regulation of cell cycle process. Located in several cellular components, including microtubule cytoskeleton; midbody; and mitochondrial matrix. Part of cyclin B1-CDK1 complex and cytoplasm. Implicated in breast cancer; cervical cancer; and urinary bladder cancer. Biomarker of breast cancer; gallbladder adenocarcinoma; hepatocellular carcinoma; and transitional cell carcinoma.
- RGD Description
- The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is a catalytic subunit of the highly conserved protein kinase complex known as M-phase promoting factor (MPF), which is essential for G2/M phase transitions of eukaryotic cell cycle. Mitotic cyclins stably associate with this protein and function as regulatory subunits. The kinase activity of this protein is controlled by cyclin accumulation and destruction through the cell cycle. The phosphorylation and dephosphorylation of this protein also play important regulatory roles in cell cycle control. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2023]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24056
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Sequence Feature Viewer
- Genome location
- Chr10:60778331...60794852 + (16.52 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction