Gene

RXFP2

Species
Homo sapiens
Symbol
RXFP2
Name
relaxin family peptide receptor 2
Synonyms
  • G protein coupled receptor affecting testicular descent
  • G-protein coupled receptor 106
Biotype
protein coding gene
Automated Description
Predicted to enable G protein-coupled peptide receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and hormone-mediated signaling pathway. Predicted to act upstream of or within male gonad development. Predicted to be located in membrane. Predicted to be active in plasma membrane. Implicated in cryptorchidism.
RGD Description
This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24372
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusRxfp210 of 10YesYes  
Rattus norvegicusRxfp210 of 10YesYes  
Xenopus laevisrxfp2.S1 of 1YesYes           
Xenopus laevisrxfp2.L1 of 1YesYes           
Xenopus tropicalisrxfp24 of 9YesYes   
Danio reriorxfp2a10 of 10YesYes  
Danio reriorxfp2b10 of 10YesYes  
Drosophila melanogasterLgr38 of 9YesYes   
Drosophila melanogasterLgr44 of 9NoYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
RXFP1174370537 of 8  
LGR4275142252 of 8  
FSHR371342242 of 8  
LGR5467542252 of 8  
TSHR571841232 of 8  
LHCGR670439242 of 8  
TLR5757137222 of 8  
IGFALS833043272 of 8  
LRRC17931743282 of 8  
VASN1028340272 of 8  
LRRC531115954352 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
GRCh38
Viewer Help
31.74M31.75M31.76M31.77M31.78M31.79M31.80MENST00000298386.7 (RXFP2)ENST00000380314.2 (RXFP2)NM_001166058.2 (RXFP2)NM_130806.5 (RXFP2)XM_017020389.2 (RXFP2)
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_000013.11:g.31781681G>T
    variant
    SNP
    • missense variant
    NC_000013.11:g.31761903C>T
      variant
      SNP
      • intron variant
      NC_000013.11:g.31789080T>C
        variant
        SNP
        • intron variant
        NC_000013.11:g.31778577A>G
          variant
          SNP
          • missense variant
          NC_000013.11:g.31786406C>T
            variant
            SNP
            • missense variant
            NC_000013.11:g.31791850G>A
              variant
              SNP
              • missense variant
              NC_000013.11:g.31739671T>G
                variant
                SNP
                • missense variant
                NC_000013.11:g.31761743G>A
                  variant
                  SNP
                  • synonymous variant
                  NC_000013.11:g.31758543T>C
                    variant
                    SNP
                    • intron variant
                    NC_000013.11:g.31765245C>T
                      variant
                      SNP
                      • intron variant
                      Showing 1 - 10 of 77 rows
                      per page

                      Transgenic Alleles

                      No data available

                      Models

                      No data available

                      Sequence Feature Viewer

                      Genome location
                      Assembly version
                      GRCh38
                      Viewer Help
                      31.74M31.75M31.76M31.77M31.78M31.79M31.80MENST00000298386.7 (RXFP2)ENST00000380314.2 (RXFP2)NM_001166058.2 (RXFP2)NM_130806.5 (RXFP2)XM_017020389.2 (RXFP2)

                      Sequence Details

                      Transcript:  Mode:

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                      Expression

                      Primary Sources
                      None
                      Other Sources
                      Must provide at least one subject
                      Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

                      Molecular Interactions

                      4 interactor genes based on 4 annotations
                      RXFP2 molecule type
                      Interactor gene
                      Interactor species
                      Interactor molecule type
                      Detection methods
                      Source
                      Reference
                      protein
                      CNPY4Homo sapiens
                      protein
                      • affinity chromatography technology
                      PMID:33961781
                      protein
                      INSL3Homo sapiens
                      protein
                      • affinity chromatography technology
                      PMID:12114498
                      protein
                      LIMK1Homo sapiens
                      protein
                      • affinity chromatography technology
                      PMID:33961781
                      protein
                      OSBPL8Homo sapiens
                      protein
                      • affinity chromatography technology
                      PMID:33961781
                      Showing 1 - 4 of 4 rows
                      per page

                      Genetic Interactions

                      No data available