Gene

CDC6

Species
Homo sapiens
Symbol
CDC6
Name
cell division cycle 6
Synonyms
  • CDC18 (cell division cycle 18, S.pombe, homolog)-like
  • cdc18-related protein
Biotype
protein coding gene
Automated Description
Enables kinase binding activity. Involved in positive regulation of chromosome segregation; positive regulation of cytokinesis; and regulation of mitotic metaphase/anaphase transition. Located in several cellular components, including intercellular bridge; nucleoplasm; and spindle. Implicated in Meier-Gorlin syndrome 5.
RGD Description
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR10763
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
40.288M40.290M40.292M40.294M40.296M40.298M40.300M40.302M40.304M

Sequence Details

Loading...

Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions