Version: 8.0.0Date: Tue Jan 28 2025
Gene
GAB3
- Species
- Homo sapiens
- Symbol
- GAB3
- Name
- GRB2 associated binding protein 3
- Synonyms
- DOS/Gab family member 3
- Gab3 scaffolding protein
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable signaling adaptor activity. Predicted to be involved in signal transduction. Predicted to act upstream of or within macrophage differentiation. Predicted to be located in membrane. Predicted to be active in cytoplasm.
- RGD Description
- This gene is a member of the GRB2-associated binding protein gene family. These proteins are scaffolding/docking proteins that are involved in several growth factor and cytokine signaling pathways, and they contain a pleckstrin homology domain, and bind SHP2 tyrosine phosphatase and GRB2 adapter protein. The protein encoded by this gene facilitates macrophage differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR46254
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
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Sequence Feature Viewer
- Genome location
- ChrX:154675249...154751583 - (76.33 kb)
- Assembly version
- GRCh38
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