DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae)
Biotype
protein coding gene
Automated Description
Enables 5'-3' DNA exonuclease activity and beta-lactamase activity. Predicted to be involved in double-strand break repair via nonhomologous end joining and interstrand cross-link repair. Predicted to act upstream of or within nucleotide-excision repair. Located in fibrillar center and nucleoplasm.
RGD Description
This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]