Gene

DCLRE1A

Species
Homo sapiens
Symbol
DCLRE1A
Name
DNA cross-link repair 1A
Synonyms
  • beta-lactamase DCLRE1A
  • DNA cross-link repair 1A (PSO2 homolog, S. cerevisiae)
Biotype
protein coding gene
Automated Description
Enables 5'-3' DNA exonuclease activity and beta-lactamase activity. Predicted to be involved in double-strand break repair via nonhomologous end joining and interstrand cross-link repair. Predicted to act upstream of or within nucleotide-excision repair. Located in fibrillar center and nucleoplasm.
RGD Description
This gene encodes a conserved protein that is involved in the repair of DNA interstrand cross-links. DNA cross-links suppress transcription, replication, and DNA segregation. The encoded protein is a regulator of the mitotic cell cycle checkpoint. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2012]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23240
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
113.836M113.838M113.840M113.842M113.844M113.846M113.848M113.850M113.852M113.854M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions