Gene

XPO5

Species
Homo sapiens
Symbol
XPO5
Name
exportin 5
Synonyms
  • exp5
  • exportin-5
Biotype
protein coding gene
Automated Description
Enables several functions, including RISC complex binding activity; nuclear export signal receptor activity; and small GTPase binding activity. Contributes to pre-miRNA binding activity. Involved in pre-miRNA export from nucleus and protein export from nucleus. Located in cytosol and nucleoplasm. Part of RISC complex and RNA nuclear export complex. Implicated in breast cancer; gastrointestinal system cancer (multiple); lung carcinoma (multiple); multiple myeloma; and primary ovarian insufficiency. Biomarker of transitional cell carcinoma.
RGD Description
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11223
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
43.525M43.530M43.535M43.540M43.545M43.550M43.555M43.560M43.565M43.570M43.575M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions