Enables several functions, including RISC complex binding activity; nuclear export signal receptor activity; and small GTPase binding activity. Contributes to pre-miRNA binding activity. Involved in pre-miRNA export from nucleus and protein export from nucleus. Located in cytosol and nucleoplasm. Part of RISC complex and RNA nuclear export complex. Implicated in breast cancer; gastrointestinal system cancer (multiple); lung carcinoma (multiple); multiple myeloma; and primary ovarian insufficiency. Biomarker of transitional cell carcinoma.
RGD Description
This gene encodes a member of the karyopherin family that is required for the transport of small RNAs and double-stranded RNA-binding proteins from the nucleus to the cytoplasm. The encoded protein translocates cargo through the nuclear pore complex in a RanGTP-dependent process. [provided by RefSeq, Aug 2011]