Version: 8.0.0Date: Tue Jan 28 2025
Gene
CDK4
- Species
- Homo sapiens
- Symbol
- CDK4
- Name
- cyclin dependent kinase 4
- Synonyms
- cell division kinase 4
- cell division protein kinase 4
- Biotype
- protein coding gene
- Automated Description
- Enables cyclin binding activity and cyclin-dependent protein serine/threonine kinase activity. Involved in several processes, including G1/S transition of mitotic cell cycle; positive regulation of G2/M transition of mitotic cell cycle; and positive regulation of fibroblast proliferation. Located in chromatin; cytosol; and nucleus. Part of cyclin D1-CDK4 complex; cyclin D2-CDK4 complex; and cyclin D3-CDK4 complex. Implicated in several diseases, including carcinoma (multiple); familial melanoma; glioblastoma; obesity; and type 2 diabetes mellitus. Biomarker of several diseases, including cervix uteri carcinoma in situ; kidney cancer (multiple); lung non-small cell carcinoma (multiple); pancreatic cancer (multiple); and transitional cell carcinoma.
- RGD Description
- The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24056
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr12:57747727...57756013 - (8.29 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.