Predicted to enable myosin binding activity. Predicted to be involved in cell-cell adhesion and synapse maturation. Predicted to act upstream of or within chordate embryonic development. Located in cytosol and nucleoplasm.
RGD Description
This gene encodes a transmembrane protein which has been localized to adherens junctions and shown to bind to myosin VIIA. Examination of expression of this gene in gastric cancer tissues have shown that expression is decreased which appears to be related to hypermethylation of the promoter. Expression of this gene may also be inhibited by binding of a specific microRNA to a target sequence in the 3' UTR of the transcripts. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011]