Gene

IFNL2

Species
Homo sapiens
Symbol
IFNL2
Name
interferon lambda 2
Synonyms
  • cytokine Zcyto20
  • IFN-lambda-2
Biotype
protein coding gene
Automated Description
Predicted to enable signaling receptor binding activity. Predicted to be involved in defense response to virus; innate immune response; and mucosal immune response. Predicted to be located in extracellular region. Predicted to be active in extracellular space.
RGD Description
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR31943
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
39.2684M39.2686M39.2688M39.2690M39.2692M39.2694M39.2696M39.2698M39.2700M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions