Gene

TMEM121B

Species
Homo sapiens
Symbol
TMEM121B
Name
transmembrane protein 121B
Synonyms
  • cat eye syndrome chromosome region, candidate 6
  • cat eye syndrome critical region protein 6
Biotype
protein coding gene
Automated Description
Not Available
RGD Description
ASSOCIATED WITH immunodeficiency 51; Neurodevelopmental Disorders; Polyarteritis Nodosa, Childhood-Onset; INTERACTS WITH 17beta-estradiol; 3,3'-diindolylmethane; aflatoxin B1
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR47399
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusTmem121b10 of 10YesYes  
Rattus norvegicusTmem121b10 of 10YesYes  
Danio reriotmem121b9 of 10YesYes  
Caenorhabditis elegansF13E9.112 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

No paralogs for the gene.

Function - GO Annotations

No function available for that gene

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
No data available

Alleles and Variants

Genome location
Assembly version
GRCh38
Viewer Help
17.1165M17.1170M17.1175M17.1180M17.1185M17.1190M17.1195M17.1200M17.1205M17.1210M
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_000022.11:g.17120304T>Gvariant
SNP
  • missense variant
NC_000022.11:g.17120932C>Tvariant
SNP
  • missense variant
NC_000022.11:g.17121055C>Tvariant
SNP
  • missense variant
NC_000022.11:g.17119999G>Avariant
SNP
  • missense variant
NC_000022.11:g.17119984G>Avariant
SNP
  • missense variant
NC_000022.11:g.17120553G>Tvariant
SNP
  • missense variant
NC_000022.11:g.17120566G>Avariant
SNP
  • missense variant
NC_000022.11:g.17120932C>Avariant
SNP
  • missense variant
NC_000022.11:g.17119564C>Tvariant
SNP
  • missense variant
NC_000022.11:g.17119894G>Cvariant
SNP
  • missense variant
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Transgenic Alleles

Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
17.1165M17.1170M17.1175M17.1180M17.1185M17.1190M17.1195M17.1200M17.1205M17.1210MENST00000331437.4 (TMEM121B)ENST00000399875.1 (TMEM121B)NM_001163079.2 (TMEM121B)NM_031890.4 (TMEM121B)XM_011546124.3 (TMEM121B)

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

2 interactor genes based on 2 annotations
TMEM121B molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
KDM5BHomo sapiens
protein
  • affinity chromatography technology
PMID:19336002
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Genetic Interactions

TMEM121B role
TMEM121B genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
EGFRHomo sapiens
unspecified role
negative genetic interaction (sensu BioGRID)
  • viability
  • Growth abnormality
PMID:31741433
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