Enables dipeptidyl-peptidase activity and identical protein binding activity. Involved in negative regulation of programmed cell death. Acts upstream of with a negative effect on pyroptotic inflammatory response. Part of cell leading edge and microtubule. Is active in cytosol. Implicated in primary immunodeficiency disease.
RGD Description
This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]