Gene

DPP9

Species
Homo sapiens
Symbol
DPP9
Name
dipeptidyl peptidase 9
Synonyms
  • dipeptidyl peptidase IV-related protein 2
  • dipeptidyl peptidase IV-related protein-2
Biotype
protein coding gene
Automated Description
Enables dipeptidyl-peptidase activity and identical protein binding activity. Involved in negative regulation of programmed cell death. Acts upstream of with a negative effect on pyroptotic inflammatory response. Part of cell leading edge and microtubule. Is active in cytosol. Implicated in primary immunodeficiency disease.
RGD Description
This gene encodes a protein that is a member of the S9B family in clan SC of the serine proteases. The protein has been shown to have post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Although the activity of this protein is similar to that of dipeptidyl peptidase 4 (DPP4), it does not appear to be membrane bound. In general, dipeptidyl peptidases appear to be involved in the regulation of the activity of their substrates and have been linked to a variety of diseases including type 2 diabetes, obesity and cancer. Several transcript variants of this gene have been described but not fully characterized. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12138
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
4.675M4.680M4.685M4.690M4.695M4.700M4.705M4.710M4.715M4.720M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions