Predicted to enable protein serine/threonine kinase activity and protein tyrosine kinase activity. Predicted to be involved in chromatin remodeling. Predicted to act upstream of or within peptidyl-serine phosphorylation; protein autophosphorylation; and regulation of signal transduction by p53 class mediator. Predicted to be active in cytoplasm and nucleus.
RGD Description
This gene encodes a member of the homeodomain interacting protein kinase (HIPK) family of proteins. While other members of this family are found throughout vertebrates, this member is present only in mammals. Compared to other members of this family, the encoded protein lacks a nuclear localization signal and a C-terminal autoinhibitory domain. The encoded protein exhibits kinase activity and may phosphorylate the tumor suppressor protein p53. [provided by RefSeq, Jul 2016]