Gene

PANK4

Species
Homo sapiens
Symbol
PANK4
Name
pantothenate kinase 4 (inactive)
Synonyms
  • 4'-phosphopantetheine phosphatase
  • CTRCT49
Biotype
protein coding gene
Automated Description
Enables phosphatase activity. Predicted to be involved in coenzyme A biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nucleus. Implicated in cataract.
RGD Description
This gene encodes a protein belonging to the pantothenate kinase family. Pantothenate kinase is a key regulatory enzyme in the biosynthesis of coenzyme A (CoA) in bacteria and mammalian cells. It catalyzes the first committed step in the universal biosynthetic pathway leading to CoA and is itself subject to regulation through feedback inhibition by CoA. This family member is most abundant in muscle but is expressed in all tissues. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12280
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusPank410 of 10YesYes  
Rattus norvegicusPank410 of 10YesYes  
Xenopus laevispank4.L1 of 1YesYes           
Xenopus laevispank4.S1 of 1YesYes           
Xenopus tropicalispank49 of 9YesYes   
Danio reriopank410 of 10YesYes  
Drosophila melanogasterCG58285 of 9YesYes   
Caenorhabditis eleganspnk-47 of 9YesYes   
Caenorhabditis eleganspnk-13 of 9NoYes   
Saccharomyces cerevisiaeCAB16 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
PANK1143352324 of 8  
PANK2240854354 of 8  
PANK3337356364 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
Autosomal dominant inheritance
Childhood onset
Juvenile onset
Nystagmus
Posterior cortical cataract
Reduced visual acuity
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Species
(carrying the transgene)
Allele symbol
Transgenic construct
Expressed components
Knock-down targets
Regulatory regions
Has Disease Annotations
Has Phenotype Annotations
Drosophila melanogasterHsap\PANK4UAS.cWa
  • UAS
Showing 1 - 1 of 1 rows
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Models

No data available

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
2.510M2.512M2.514M2.516M2.518M2.520M2.522M2.524M2.526M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

77 interactor genes based on 80 annotations
PANK4 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ACTR2Homo sapiens
protein
  • biochemical
PMID:22863883
protein
AGBL4Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
AIFM1Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
ANTXR1Homo sapiens
protein
  • affinity chromatography technology
PMID:34285210
protein
AQP3Homo sapiens
protein
  • affinity chromatography technology
PMID:33961781
protein
ARHGAP24Homo sapiens
protein
  • affinity chromatography technology
PMID:36168627
protein
BAG1Homo sapiens
protein
  • biochemical
PMID:22863883
protein
BAP1Homo sapiens
protein
  • affinity chromatography technology
PMID:35446349
protein
BCL2L14Homo sapiens
protein
  • affinity chromatography technology
PMID:30833792
protein
BRD1Homo sapiens
protein
  • affinity chromatography technology
PMID:31753913
Showing 1 - 10 of 80 rows
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Genetic Interactions

No data available