Gene

AARS1

Species
Homo sapiens
Symbol
AARS1
Name
alanyl-tRNA synthetase 1
Synonyms
  • AARS
  • alanine tRNA ligase 1, cytoplasmic
Biotype
protein coding gene
Automated Description
Enables alanine-tRNA ligase activity; aminoacyl-tRNA editing activity; and peptide lactyltransferase (ATP-dependent) activity. Involved in alanyl-tRNA aminoacylation; negative regulation of signal transduction by p53 class mediator; and positive regulation of hippo signaling. Located in cytosol. Is active in cytoplasm and nucleus. Implicated in Charcot-Marie-Tooth disease axonal type 2N; developmental and epileptic encephalopathy 29; leukodystrophy; and trichothiodystrophy.
RGD Description
The human alanyl-tRNA synthetase (AARS) belongs to a family of tRNA synthases, of the class II enzymes. Class II tRNA synthases evolved early in evolution and are highly conserved. This is reflected by the fact that 498 of the 968-residue polypeptide human AARS shares 41% identity witht the E.coli protein. tRNA synthases are the enzymes that interpret the RNA code and attach specific aminoacids to the tRNAs that contain the cognate trinucleotide anticodons. They consist of a catalytic domain which interacts with the amino acid acceptor-T psi C helix of the tRNA, and a second domain which interacts with the rest of the tRNA structure. [provided by RefSeq, Jul 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11777
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
AARS2198464468 of 8  
AARSD1248537222 of 8  
PTGES3L-AARSD1345937222 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
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70.255M70.260M70.265M70.270M70.275M70.280M70.285M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions