Version: 8.1.0Date: Fri Apr 18 2025
Gene
CLCA1
- Species
- Homo sapiens
- Symbol
- CLCA1
- Name
- chloride channel accessory 1
- Synonyms
- CACC
- CaCC-1
- Biotype
- protein coding gene
- Automated Description
- Predicted to enable intracellularly calcium-gated chloride channel activity. Predicted to be involved in monoatomic ion transmembrane transport. Predicted to be located in extracellular region; microvillus; and zymogen granule membrane. Predicted to be active in plasma membrane. Implicated in asthma and chronic obstructive pulmonary disease. Biomarker of chronic obstructive pulmonary disease and cystic fibrosis.
- RGD Description
- This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR10579
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr1:86468368...86500259 + (31.89 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.