Gene

CYP26B1

Species
Homo sapiens
Symbol
CYP26B1
Name
cytochrome P450 family 26 subfamily B member 1
Synonyms
  • CYP26A2
  • cytochrome P450 26A2
Biotype
protein coding gene
Automated Description
Enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen; retinoic acid 4-hydroxylase activity; and retinoic acid binding activity. Involved in bone morphogenesis; retinoic acid catabolic process; and xenobiotic metabolic process. Located in cytoplasm. Biomarker of hepatocellular carcinoma.
RGD Description
This gene encodes a member of the cytochrome P450 superfamily. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein is localized to the endoplasmic reticulum, and functions as a critical regulator of all-trans retinoic acid levels by the specific inactivation of all-trans retinoic acid to hydroxylated forms. Mutations in this gene are associated with radiohumeral fusions and other skeletal and craniofacial anomalies, and increased levels of the encoded protein are associated with atherosclerotic lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2013]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR24286
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
72.130M72.132M72.134M72.136M72.138M72.140M72.142M72.144M72.146M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions