Gene

UFM1

Species
Homo sapiens
Symbol
UFM1
Name
ubiquitin fold modifier 1
Synonyms
  • bA131P10.1
  • BM-002
Biotype
protein coding gene
Automated Description
Involved in several processes, including negative regulation of protein import into nucleus; protein K69-linked ufmylation; and reticulophagy. Acts upstream of or within response to endoplasmic reticulum stress. Located in cytoplasm and nucleus. Implicated in hypomyelinating leukodystrophy 14.
RGD Description
UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1; MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M; MIM 603173) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Dec 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15825
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
38.350M38.352M38.354M38.356M38.358M38.360M38.362M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions