Version: 8.0.0
Date: Tue Jan 28 2025
SCD5
Homo sapiensHGNC:21088
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

SCD5

Species
Homo sapiens
Symbol
SCD5
Name
stearoyl-CoA desaturase 5
Synonyms
  • ACOD4
  • acyl-CoA-desaturase 4
Biotype
protein coding gene
Automated Description
Enables stearoyl-CoA 9-desaturase activity. Involved in unsaturated fatty acid biosynthetic process. Located in endoplasmic reticulum membrane. Implicated in autosomal dominant nonsyndromic deafness 79.
RGD Description
Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an integral membrane protein of the endoplasmic reticulum that catalyzes the formation of monounsaturated fatty acids from saturated fatty acids. SCD may be a key regulator of energy metabolism with a role in obesity and dislipidemia. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 (MIM 604031) and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM, Mar 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11351
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Danio rerioscd5 of 10YesYes☐ ☑☑☑☐☑☐☐☑ ☐
Danio rerioscdb5 of 10YesYes☐ ☑☑☑☐☑☐☐☑ ☐
Drosophila melanogasterDesat29 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Drosophila melanogasterDesat19 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Drosophila melanogasterFad28 of 9NoYes☑ ☑☑☐☑☑☑☑☑  
Drosophila melanogasterCG86307 of 9NoYes☑ ☑☐☑☑☑☑☑☐  
Drosophila melanogasterCG97435 of 9NoYes☑ ☑☐☐☑☐☑☑☐  
Drosophila melanogasterCG97475 of 9NoYes☑ ☑☐☐☑☐☑☑☐  
Drosophila melanogasterCG155314 of 9NoYes☑ ☐☐☐☑☐☑☑☐  
Caenorhabditis elegansfat-69 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Caenorhabditis elegansfat-79 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Caenorhabditis elegansfat-59 of 9YesYes☑ ☑☑☑☑☑☑☑☑  
Saccharomyces cerevisiaeOLE15 of 9YesYes☐ ☑☑☐☑☑☐☐☑  
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
SCD131577617 of 8☑ ☑☐☑☑☑☑☑ 

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
Abnormal vestibular function
Adult onset
Autosomal dominant inheritance
Progressive sensorineural hearing impairment
Showing 1 - 4 of 4 rows
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Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species
Gene
Association
Disease Qualifier
Disease
Evidence
Source
Based On
References
No records match query. Try removing filters.
Showing 0 - 0 of 0 rows
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    Alleles and Variants

    Genome location
    Assembly version
    GRCh38
    Viewer Help
    Data currently unavailable; sequence viewer under construction
    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
    NC_000004.12:g.82636670G>Avariant
    SNP
    • synonymous variant
    NC_000004.12:g.82798444C>Tvariant
    SNP
    • missense variant
    NC_000004.12:g.82798420C>Gvariant
    SNP
    • missense variant
    NC_000004.12:g.82631385C>Tvariant
    SNP
    • missense variant
    NC_000004.12:g.82636609C>Tvariant
    SNP
    • missense variant
    NC_000004.12:g.82705408A>Tvariant
    SNP
    • missense variant
    NC_000004.12:g.82798521G>Cvariant
    SNP
    • missense variant
    NC_000004.12:g.82636705T>Cvariant
    SNP
    • missense variant
    NC_000004.12:g.82798459A>Gvariant
    SNP
    • missense variant
    NC_000004.12:g.82636662A>Gvariant
    SNP
    • missense variant
    Showing 1 - 10 of 23 rows
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    View detailed Alleles/Variants information
    Download all Alleles/Variants for all genes of the species

    Transgenic Alleles

    No data available

    Models

    No data available

    Sequence Feature Viewer

    Genome location
    Assembly version
    GRCh38
    Viewer Help
    Data currently unavailable; sequence viewer under construction

    Sequence Details

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    Expression

    Primary Sources
    None
    Other Sources
    Must provide at least one subject
    Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

    Molecular Interactions

    56 interactor genes based on 65 annotations
    SCD5 molecule type
    Interactor gene
    Interactor species
    Interactor molecule type
    Detection methods
    Source
    Reference
    protein
    		ATG9AHomo sapiens
    protein
    • proximity labelling technology
    		PMID:34369648
    protein
    		ATP2A1Homo sapiens
    protein
    • proximity labelling technology
    		PMID:34079125
    protein
    		ATP2A3Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		BCAP31Homo sapiens
    protein
    • proximity labelling technology
    		PMID:34079125
    protein
    		CDC123Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:37314216
    protein
    		CHRNA1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:33961781
    protein
    		CKAP4Homo sapiens
    protein
    • proximity labelling technology
    		PMID:34079125
    protein
    		CNDP1Homo sapiens
    protein
    • affinity chromatography technology
    		PMID:26186194
    protein
    		DERL1Homo sapiens
    protein
    • proximity labelling technology
    		PMID:34079125
    protein
    		DNAJC25Homo sapiens
    protein
    • proximity labelling technology
    		PMID:33957083
    Showing 1 - 10 of 65 rows
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    Genetic Interactions

    No data available