Gene

COBL

Species
Homo sapiens
Symbol
COBL
Name
cordon-bleu WH2 repeat protein
Synonyms
  • cordon-bleu homolog
  • DKFZp686G13227
Biotype
protein coding gene
Automated Description
Predicted to enable actin monomer binding activity. Predicted to be involved in several processes, including actin filament organization; chordate embryonic development; and collateral sprouting in absence of injury. Predicted to act upstream of or within actin cytoskeleton organization. Predicted to be located in several cellular components, including actin filament; axon; and dendrite. Predicted to be active in several cellular components, including growth cone; ruffle; and terminal web.
RGD Description
This gene encodes a protein that contains WH2 domains (WASP, Wiskott-Aldrich syndrome protein, homology domain-2) that interact with actin. The encoded actin regulator protein is required for growth and assembly of brush border microvilli that play a role in maintaining intestinal homeostasis. A similar protein in mouse functions in midbrain neural tube closure. A pseudogene of this gene is located on chromosome X. [provided by RefSeq, Oct 2016]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR47008
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
51.05M51.10M51.15M51.20M51.25M51.30M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions