Predicted to enable actin monomer binding activity. Predicted to be involved in several processes, including actin filament organization; chordate embryonic development; and collateral sprouting in absence of injury. Predicted to act upstream of or within actin cytoskeleton organization. Predicted to be located in several cellular components, including actin filament; axon; and dendrite. Predicted to be active in several cellular components, including growth cone; ruffle; and terminal web.
RGD Description
This gene encodes a protein that contains WH2 domains (WASP, Wiskott-Aldrich syndrome protein, homology domain-2) that interact with actin. The encoded actin regulator protein is required for growth and assembly of brush border microvilli that play a role in maintaining intestinal homeostasis. A similar protein in mouse functions in midbrain neural tube closure. A pseudogene of this gene is located on chromosome X. [provided by RefSeq, Oct 2016]