Species

Homo sapiens

Symbol

CREB3

Name

cAMP responsive element binding protein 3

Synonyms

basic leucine zipper protein
cAMP-responsive element-binding protein 3

Biotype

protein coding gene

Automated Description

Enables several functions, including CCR1 chemokine receptor binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and cAMP response element binding protein binding activity. Involved in several processes, including positive regulation of chemotaxis; positive regulation of deacetylase activity; and regulation of DNA-templated transcription. Located in several cellular components, including Golgi membrane; neuronal cell body; and nuclear body. Part of RNA polymerase II transcription regulator complex.

RGD Description

This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.[provided by RefSeq, Nov 2009]

Cross References

Additional Information

Literature

Orthology

Gene tree: PANTHER:PTHR45996

No data available

Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources

None

Other Sources

BioGRID CRISPR Screen Cell Line Phenotypes

Phenotype Term	Annotation details	References
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Disease Associations

Cell color indicative of annotation volume

Gene	Association	Disease Qualifier	Disease	Evidence	Source	Based On	References
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Alleles and Variants

Allele/Variant Symbol	Allele Synonyms	Category	Variant	Variant type	Molecular consequence	Has Disease Annotations	Has Phenotype Annotations
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Download all Alleles/Variants for all genes of the species

Transgenic Alleles

Species (carrying the transgene)	Allele symbol	Transgenic construct	Expressed components	Knock-down targets	Regulatory regions	Has Disease Annotations	Has Phenotype Annotations
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Models

Model name	Experimental condition	Associated Human Diseases	Associated Phenotypes	Modifier	Source
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Sequence Feature Viewer

Genome location

Chr9:35732598...35736999 + (4.40 kb)

Assembly version

GRCh38

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Sequence Details

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Expression

Primary Sources

None

Other Sources

Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

CREB3 molecule type	Interactor gene	Interactor species	Interactor molecule type	Detection methods	Source	Reference
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Genetic Interactions

CREB3 role	CREB3 genetic perturbation	Interactor gene	Interactor species	Interactor role	Interactor genetic perturbation	Interaction type	Phenotype or trait	Source	Reference
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