Enables cytokine binding activity. Contributes to ciliary neurotrophic factor receptor binding activity and cytokine activity. Involved in cell surface receptor signaling pathway via STAT; negative regulation of neuron apoptotic process; and positive regulation of cell population proliferation. Part of CRLF-CLCF1 complex. Implicated in cold-induced sweating syndrome 1.
RGD Description
This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]