Gene

CRLF1

Species
Homo sapiens
Symbol
CRLF1
Name
cytokine receptor like factor 1
Synonyms
  • CISS
  • CISS1
Biotype
protein coding gene
Automated Description
Enables cytokine binding activity. Contributes to ciliary neurotrophic factor receptor binding activity and cytokine activity. Involved in cell surface receptor signaling pathway via STAT; negative regulation of neuron apoptotic process; and positive regulation of cell population proliferation. Part of CRLF-CLCF1 complex. Implicated in cold-induced sweating syndrome 1.
RGD Description
This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR23036
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
18.575M18.580M18.585M18.590M18.595M18.600M18.605M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions