Gene

AKR7L

Species
Homo sapiens
Symbol
AKR7L
Name
aldo-keto reductase family 7 like (gene/pseudogene)
Synonyms
  • AFAR3
  • AFB1 aldehyde reductase 3
Biotype
protein coding gene
Automated Description
Predicted to enable aldo-keto reductase (NADPH) activity. Located in extracellular exosome.
RGD Description
This gene is one of three aldo-keto reductase genes that are present in a cluster on the p arm of chromosome 1. The encoded proteins are involved in the reduction of the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. It has been speculated that this family member encodes a selenoprotein, which includes a selenocysteine (Sec) residue in lieu of a UGA translational termination codon. However, there is no evidence that such a protein is produced in vivo. The alternative interpretation is that this family member is a segregating pseudogene, where some individuals have an allele that encodes a functional enzyme, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Feb 2017]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR43364
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            19.266M19.267M19.268M19.269M19.270M19.271M19.272M19.273M19.274M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            AKR7L molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              AKR7L role
              AKR7L genetic perturbation
              Interactor gene
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