Gene

DSCC1

Species
Homo sapiens
Symbol
DSCC1
Name
DNA replication and sister chromatid cohesion 1
Synonyms
  • DCC1
  • defective in sister chromatid cohesion 1 homolog
Biotype
protein coding gene
Automated Description
Contributes to DNA clamp loader activity and single-stranded DNA helicase activity. Involved in maintenance of mitotic sister chromatid cohesion; positive regulation of DNA-directed DNA polymerase activity; and post-translational protein acetylation. Located in chromatin; chromosome, centromeric region; and nucleoplasm. Part of Ctf18 RFC-like complex.
RGD Description
CHTF18 (MIM 613201), CHTF8 (MIM 613202), and DSCC1 are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13395
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
119.834M119.836M119.838M119.840M119.842M119.844M119.846M119.848M119.850M119.852M119.854M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions