Gene

NEIL3

Species
Homo sapiens
Symbol
NEIL3
Name
nei like DNA glycosylase 3
Synonyms
  • DNA glycosylase FPG2
  • DNA glycosylase hFPG2
Biotype
protein coding gene
Automated Description
Enables DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) endonuclease activity; and single-stranded DNA binding activity. Involved in base-excision repair and single strand break repair. Located in nucleoplasm. Biomarker of hepatocellular carcinoma.
RGD Description
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR22993
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
177.31M177.32M177.33M177.34M177.35M177.36M177.37M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions