Enables DNA N-glycosylase activity; DNA-(apurinic or apyrimidinic site) endonuclease activity; and single-stranded DNA binding activity. Involved in base-excision repair and single strand break repair. Located in nucleoplasm. Biomarker of hepatocellular carcinoma.
RGD Description
NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]