Version: 8.0.0
Date: Tue Jan 28 2025
FTO
Homo sapiensHGNC:24678
SummaryOrthologyParalogyFunction - GO AnnotationsPathwaysPhenotypesDisease AssociationsAlleles and VariantsTransgenic AllelesModelsSequence Feature ViewerSequence DetailsExpressionMolecular InteractionsGenetic Interactions
Gene

FTO

Species
Homo sapiens
Symbol
FTO
Name
FTO alpha-ketoglutarate dependent dioxygenase
Synonyms
  • AlkB homolog 9
  • ALKBH9
Biotype
protein coding gene
Automated Description
Enables 2-oxoglutarate-dependent dioxygenase activity and ferrous iron binding activity. Involved in several processes, including DNA alkylation repair; RNA metabolic process; and mRNA destabilization. Located in cytosol; nuclear speck; and plasma membrane. Implicated in several diseases, including artery disease (multiple); diabetic neuropathy; nuclear senile cataract; renal cell carcinoma (multiple); and type 2 diabetes mellitus. Biomarker of abdominal aortic aneurysm; clear cell renal cell carcinoma; congestive heart failure; multiple myeloma; and type 2 diabetes mellitus.
RGD Description
This gene is a nuclear protein of the AlkB related non-haem iron and 2-oxoglutarate-dependent oxygenase superfamily but the exact physiological function of this gene is not known. Other non-heme iron enzymes function to reverse alkylated DNA and RNA damage by oxidative demethylation. Studies in mice and humans indicate a role in nervous and cardiovascular systems and a strong association with body mass index, obesity risk, and type 2 diabetes. [provided by RefSeq, Jul 2011]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12138
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    No data available

    Alleles and Variants

    Allele/Variant Symbol
    Allele Synonyms
    Category
    Variant
    Variant type
    Molecular consequence
    Has Disease Annotations
    Has Phenotype Annotations
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      Transgenic Alleles

      Species
      (carrying the transgene)
      Allele symbol
      Transgenic construct
      Expressed components
      Knock-down targets
      Regulatory regions
      Has Disease Annotations
      Has Phenotype Annotations
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        Models

        Model name
        Experimental condition
        Associated Human Diseases
        Associated Phenotypes
        Modifier
        Source
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          Sequence Feature Viewer

          Genome location
          Assembly version
          GRCh38
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          Data currently unavailable; sequence viewer under construction

          Sequence Details

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          Expression

          Primary Sources
          None
          Other Sources
          Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

          Molecular Interactions

          FTO molecule type
          Interactor gene
          Interactor species
          Interactor molecule type
          Detection methods
          Source
          Reference
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            Genetic Interactions

            FTO role
            FTO genetic perturbation
            Interactor gene
            Interactor species
            Interactor role
            Interactor genetic perturbation
            Interaction type
            Phenotype or trait
            Source
            Reference
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