Gene

FATE1

Species
Homo sapiens
Symbol
FATE1
Name
fetal and adult testis expressed 1
Synonyms
  • BJ-HCC-2 antigen
  • cancer/testis antigen 43
Biotype
protein coding gene
Automated Description
Enables identical protein binding activity and ubiquitin protein ligase binding activity. Involved in negative regulation of apoptotic process and negative regulation of mitochondrial calcium ion concentration. Located in endoplasmic reticulum; mitochondria-associated endoplasmic reticulum membrane contact site; and mitochondrial outer membrane.
RGD Description
This gene encodes a cancer-testis antigen that is highly expressed in hepatocellular carcinomas and other tumors and weakly expressed in normal tissues except testis. The protein is strongly expressed in spermatogonia, primary spermatocytes, and Sertoli cells in seminiferous tubules. This protein may have a role in the control of early testicular differentiation and cell proliferation. [provided by RefSeq, Jan 2010]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21128
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
151.717M151.718M151.719M151.720M151.721M151.722M151.723M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions