Gene

DPH7

Species
Homo sapiens
Symbol
DPH7
Name
diphthamide biosynthesis 7
Synonyms
  • C9orf112
  • chromosome 9 open reading frame 112
Biotype
protein coding gene
Automated Description
Predicted to enable diphthine methylesterase activity. Involved in protein histidyl modification to diphthamide. Predicted to be active in cytoplasm.
RGD Description
Diphthamide is a post-translationally modified histidine residue present in elongation factor 2, and is the target of diphtheria toxin. This gene encodes a protein that contains a WD-40 domain, and is thought to be involved in diphthamide biosynthesis. A similar protein in yeast functions as a methylesterase, converting methylated diphthine to diphthine, which can then undergo amidation to produce diphthamide. [provided by RefSeq, Oct 2016]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46042
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
137.556M137.558M137.560M137.562M137.564M137.566M137.568M137.570M137.572M137.574M137.576M137.578M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions