Gene

ANO6

Species
Homo sapiens
Symbol
ANO6
Name
anoctamin 6
Synonyms
  • anoctamin-6
  • BDPLT7
Biotype
protein coding gene
Automated Description
Enables monoatomic ion channel activity and phospholipid scramblase activity. Involved in several processes, including bleb assembly; monoatomic ion transmembrane transport; and positive regulation of blood coagulation. Located in cytosol and plasma membrane. Part of chloride channel complex. Implicated in Scott syndrome; ankylosing spondylitis; and inflammatory bowel disease.
RGD Description
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR12308
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
45.25M45.30M45.35M45.40M45.45M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions