Gene

ZCCHC8

Species
Homo sapiens
Symbol
ZCCHC8
Name
zinc finger CCHC-type containing 8
Synonyms
  • DKFZp434E2220
  • PFBMFT5
Biotype
protein coding gene
Automated Description
Enables RNA binding activity. Involved in co-transcriptional lncRNA 3' end processing, cleavage and polyadenylation pathway and mRNA 3'-end processing. Located in nuclear body. Part of TRAMP complex and catalytic step 2 spliceosome.
RGD Description
This gene encodes a scaffold protein which serves as an assessory factor to the nuclear RNA exosome complex. The encoded protein forms a trimeric human nuclear exosome targeting (NEXT) complex, together with hMTR4 and the RNA-binding factor RBM7 which promotes the exosomal degradation of non-coding promoter-upstream transcripts, enhancer RNAs and 3'-extended products of histone- and small nuclear RNA transcription. This complex is also thought to recruit the exosome to degrade intronic RNAs via its interaction with both the exosome and the spliceosome. It contains both an N-terminal zinc-knuckle domain and a C-terminal proline-rich domain. [provided by RefSeq, Apr 2017]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR13316
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
122.475M122.480M122.485M122.490M122.495M122.500M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions