Gene

PRMT7

Species
Homo sapiens
Symbol
PRMT7
Name
protein arginine methyltransferase 7
Synonyms
  • [Myelin basic protein]-arginine N-methyltransferase PRMT7
  • FLJ10640
Biotype
protein coding gene
Automated Description
Enables histone binding activity; protein methyltransferase activity; and ribonucleoprotein complex binding activity. Involved in peptidyl-arginine methylation and spliceosomal snRNP assembly. Located in cytosol; fibrillar center; and nucleoplasm.
RGD Description
This gene encodes a member of the protein arginine N-methyltransferase family of proteins. The encoded enzyme transfers single methyl groups to arginine residues to generate monomethylarginines on histone proteins as well as other protein substrates. This enzyme plays a role in a wide range of biological processes, including neuronal differentiation, male germ line imprinting, small nuclear ribonucleoprotein biogenesis, and regulation of the Wnt signaling pathway. Mutations in this gene underlie multiple related syndromes in human patients characterized by intellectual disability, short stature and other features. The encoded protein may promote breast cancer cell invasion and metastasis in human patients. [provided by RefSeq, May 2017]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR11006
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
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68.315M68.320M68.325M68.330M68.335M68.340M68.345M68.350M68.355M68.360M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions