alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide
Synonyms
ADH-4
ADH4
Biotype
protein coding gene
Automated Description
Enables several functions, including alcohol binding activity; aldehyde oxidase activity; and all-trans-retinol dehydrogenase (NAD+) activity. Involved in several processes, including fatty acid omega-oxidation; response to ethanol; and retinoid metabolic process. Located in cytosol and plasma membrane.
RGD Description
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]