Gene

THNSL2

Species
Homo sapiens
Symbol
THNSL2
Name
threonine synthase like 2
Synonyms
  • FLJ10916
  • FLJ35504
Biotype
protein coding gene
Automated Description
Predicted to enable pyridoxal phosphate binding activity and serine binding activity. Predicted to be involved in 2-oxobutyrate biosynthetic process; dephosphorylation; and serine family amino acid catabolic process. Predicted to be located in extracellular space.
RGD Description
This gene encodes a threonine synthase-like protein. A similar enzyme in mouse can catalyze the degradation of O-phospho-homoserine to a-ketobutyrate, phosphate, and ammonia. This protein also has phospho-lyase activity on both gamma and beta phosphorylated substrates. In mouse an alternatively spliced form of this protein has been shown to act as a cytokine and can induce the production of the inflammatory cytokine IL6 in osteoblasts. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2011]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR42690
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
88.172M88.174M88.176M88.178M88.180M88.182M88.184M88.186M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions