Version: 8.0.0Date: Tue Jan 28 2025
Gene
WDR33
- Species
- Homo sapiens
- Symbol
- WDR33
- Name
- WD repeat domain 33
- Synonyms
- FLJ11294
- NET14
- Biotype
- protein coding gene
- Automated Description
- Enables RNA binding activity. Predicted to be involved in postreplication repair and spermatogenesis. Located in fibrillar center and nucleoplasm.
- RGD Description
- This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is highly expressed in testis and the protein is localized to the nucleus. This gene may play important roles in the mechanisms of cytodifferentiation and/or DNA recombination. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR22836
Stringency:
Additional filters to further constrain the results:
| Species | Gene symbol | Count | Best | Best reverse | Method Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN |
|---|---|---|---|---|---|
| Mus musculus | Wdr33 | 10 of 10 | Yes | Yes | ☑☑☑☑☑☑☑☑☑☑ |
| Rattus norvegicus | Wdr33 | 10 of 10 | Yes | Yes | ☑☑☑☑☑☑☑☑☑☑ |
| Xenopus laevis | wdr33.S | 1 of 1 | Yes | Yes | ☑ |
| Xenopus laevis | wdr33.L | 1 of 1 | Yes | Yes | ☑ |
| Xenopus tropicalis | wdr33 | 9 of 9 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ |
| Danio rerio | wdr33 | 10 of 10 | Yes | Yes | ☑ ☑☑☑☑☑☑☑☑ ☑ |
| Drosophila melanogaster | Wdr33 | 8 of 9 | Yes | Yes | ☑ ☑☑☐☑☑☑☑☑ |
| Caenorhabditis elegans | pfs-2 | 8 of 9 | Yes | Yes | ☑ ☑☑☐☑☑☑☑☑ |
| Saccharomyces cerevisiae | PFS2 | 6 of 9 | Yes | Yes | ☑ ☐☐☐☑☑☑☑☑ |
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Disease Associations
Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume
Species | Gene | Association | Disease Qualifier | Disease | Evidence | Source | Based On | References |
|---|---|---|---|---|---|---|---|---|
| No records match query. Try removing filters. | ||||||||
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Alleles and Variants
- Genome location
- Chr2:127701027...127811187 - (110.16 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
|---|---|---|---|---|---|---|---|
| NC_000002.12:g.127706366G>A | variant | SNP
| |||||
| NC_000002.12:g.127706412G>A | variant | SNP
| |||||
| NC_000002.12:g.127702105G>A | variant | SNP
| |||||
| NC_000002.12:g.127709740G>A | variant | SNP
| |||||
| NC_000002.12:g.127713725G>A | variant | SNP
| |||||
| NC_000002.12:g.127713821G>A | variant | SNP
| |||||
| NC_000002.12:g.127714013G>A | variant | SNP
| |||||
| NC_000002.12:g.127719807T>C | variant | SNP
| |||||
| NC_000002.12:g.127719932C>T | variant | SNP
| |||||
| NC_000002.12:g.127720134G>A | variant | SNP
| |||||
Sequence Feature Viewer
- Genome location
- Chr2:127701027...127811187 - (110.16 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.
Molecular Interactions
152 interactor genes based on 197 annotations
WDR33 molecule type | Interactor gene | Interactor species | Interactor molecule type | Detection methods | Source | Reference |
|---|---|---|---|---|---|---|
protein | AHCYL1 | Homo sapiens | protein |
| PMID:33961781 | |
protein | AHCYL2 | Homo sapiens | protein |
| PMID:28514442 | |
protein | AIF1 | Homo sapiens | protein |
| PMID:33961781 | |
protein | ALG13 | Homo sapiens | protein |
| PMID:29395067 | |
protein | Anapc5 | Mus musculus | protein |
| PMID:26496610 | |
protein | AR | Homo sapiens | protein |
| PMID:33640491 | |
protein | ARHGAP4 | Homo sapiens | protein |
| PMID:32203420 | |
protein | ARRDC3 | Homo sapiens | protein |
| PMID:38270169 | |
protein | ATG16L1 | Homo sapiens | protein |
| PMID:30196744 | |
protein | B9D2 | Homo sapiens | protein |
| PMID:26638075 |
Genetic Interactions
WDR33 role | WDR33 genetic perturbation | Interactor gene | Interactor species | Interactor role | Interactor genetic perturbation | Interaction type | Phenotype or trait | Source | Reference |
|---|---|---|---|---|---|---|---|---|---|
unspecified role | ATRX | Homo sapiens | unspecified role | synthetic lethality (sensu BioGRID) |
| PMID:31551363 | |||
unspecified role | EGFR | Homo sapiens | unspecified role | negative genetic interaction (sensu BioGRID) |
| PMID:34373451 |
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