Enables DNA-binding transcription factor binding activity; K63-linked polyubiquitin modification-dependent protein binding activity; and NAD+-protein poly-ADP-ribosyltransferase activity. Involved in several processes, including post-translational protein modification; regulation of macromolecule metabolic process; and translesion synthesis. Located in Golgi apparatus; cytosol; and nucleolus.
RGD Description
Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]