Gene

PARP10

Species
Homo sapiens
Symbol
PARP10
Name
poly(ADP-ribose) polymerase family member 10
Synonyms
  • ADP-ribosyltransferase diphtheria toxin-like 10
  • ARTD10
Biotype
protein coding gene
Automated Description
Enables DNA-binding transcription factor binding activity; K63-linked polyubiquitin modification-dependent protein binding activity; and NAD+-protein poly-ADP-ribosyltransferase activity. Involved in several processes, including post-translational protein modification; regulation of macromolecule metabolic process; and translesion synthesis. Located in Golgi apparatus; cytosol; and nucleolus.
RGD Description
Poly(ADP-ribose) polymerases (PARPs), such as PARP10, regulate gene transcription by altering chromatin organization by adding ADP-ribose to histones. PARPs can also function as transcriptional cofactors (Yu et al., 2005 [PubMed 15674325]).[supplied by OMIM, Mar 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR14453
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources

Disease Associations

Cases where the expected disease association was NOT found
Cell color indicative of annotation volume

Transgenic Alleles

Models

Sequence Feature Viewer

Genome location
Assembly version
GRCh38
Viewer Help
143.980M143.985M143.990M143.995M144.000M144.005M144.010M

Sequence Details

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Expression

Primary Sources
None
Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

Genetic Interactions