Gene

CHCHD4

Species
Homo sapiens
Symbol
CHCHD4
Name
coiled-coil-helix-coiled-coil-helix domain containing 4
Synonyms
  • coiled-coil-helix-coiled-coil-helix domain-containing protein 4
  • FLJ31709
Biotype
protein coding gene
Automated Description
Enables protein-disulfide reductase activity. Involved in mitochondrial respiratory chain complex assembly; peptidyl-cysteine oxidation; and protein folding. Located in mitochondrial intermembrane space.
RGD Description
CHCHD4, a component of human mitochondria, belongs to a protein family whose members share 6 highly conserved cysteine residues constituting a -CXC-CX(9)C-CX(9)C- motif in the C terminus (Hofmann et al., 2005 [PubMed 16185709]).[supplied by OMIM, Mar 2008]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR21622
No data available
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
Phenotype Term
Annotation details
References
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
    Association
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      Alleles and Variants

      Allele/Variant Symbol
      Allele Synonyms
      Category
      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            14.114M14.116M14.118M14.120M14.122M14.124M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            CHCHD4 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
            Detection methods
            Source
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              Genetic Interactions

              CHCHD4 role
              CHCHD4 genetic perturbation
              Interactor gene
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              Interactor role
              Interactor genetic perturbation
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              Phenotype or trait
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