Gene

HVCN1

Species
Homo sapiens
Symbol
HVCN1
Name
hydrogen voltage gated channel 1
Synonyms
  • HV1
  • hydrogen voltage-gated channel 1
Biotype
protein coding gene
Automated Description
Enables protein homodimerization activity and voltage-gated proton channel activity. Involved in several processes, including cellular response to zinc ion; proton transmembrane transport; and regulation of reactive oxygen species biosynthetic process. Located in phagocytic vesicle membrane; plasma membrane; and sperm flagellum.
RGD Description
This gene encodes a voltage-gated protein channel protein expressed more highly in certain cells of the immune system. Phagocytic cells produce superoxide anions which require this channel protein, and in B cells this same process facilitates antibody production. This same channel protein, however, can also regulate functions in other cells including spermatozoa. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR46480
No data available
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Paralogy

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
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Annotation details
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    Disease Associations

    Cases where the expected disease association was NOT found
    Cell color indicative of annotation volume
    Gene
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      Alleles and Variants

      Allele/Variant Symbol
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      Variant
      Variant type
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        Transgenic Alleles

        Species
        (carrying the transgene)
        Allele symbol
        Transgenic construct
        Expressed components
        Knock-down targets
        Regulatory regions
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          Models

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            Sequence Feature Viewer

            Genome location
            Assembly version
            GRCh38
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            110.63M110.64M110.65M110.66M110.67M110.68M110.69M110.70M

            Sequence Details

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            Expression

            Primary Sources
            None
            Other Sources
            Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

            Molecular Interactions

            HVCN1 molecule type
            Interactor gene
            Interactor species
            Interactor molecule type
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              Genetic Interactions

              HVCN1 role
              HVCN1 genetic perturbation
              Interactor gene
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