Version: 8.0.0Date: Tue Jan 28 2025
Gene
ADRB2
- Species
- Homo sapiens
- Symbol
- ADRB2
- Name
- adrenoceptor beta 2
- Synonyms
- ADRB2R
- ADRBR
- Biotype
- protein coding gene
- Automated Description
- Enables several functions, including amyloid-beta binding activity; beta2-adrenergic receptor activity; and norepinephrine binding activity. Involved in several processes, including AMPA selective glutamate receptor signaling pathway; positive regulation of macroautophagy; and regulation of signal transduction. Located in Golgi apparatus and plasma membrane. Part of receptor complex. Implicated in several diseases, including autoimmune disease (multiple); disease of metabolism (multiple); kidney failure (multiple); lung disease (multiple); and open-angle glaucoma (multiple). Biomarker of cholangiocarcinoma; chronic obstructive pulmonary disease; cystic fibrosis; and psoriasis.
- RGD Description
- This gene encodes beta-2-adrenergic receptor which is a member of the G protein-coupled receptor superfamily. This receptor is directly associated with one of its ultimate effectors, the class C L-type calcium channel Ca(V)1.2. This receptor-channel complex also contains a G protein, an adenylyl cyclase, cAMP-dependent kinase, and the counterbalancing phosphatase, PP2A. The assembly of the signaling complex provides a mechanism that ensures specific and rapid signaling by this G protein-coupled receptor. This receptor is also a transcription regulator of the alpha-synuclein gene, and together, both genes are believed to be associated with risk of Parkinson's Disease. This gene is intronless. Different polymorphic forms, point mutations, and/or downregulation of this gene are associated with nocturnal asthma, obesity, type 2 diabetes and cardiovascular disease. [provided by RefSeq, Oct 2019]
- Cross References
- Additional Information
- Literature
Orthology
- Gene tree
- PANTHER:PTHR24248
Links to orthology data in JBrowse by filter level: Stringent, Moderate, No filter, Best and Best Reverse
Phenotypes
- Primary Sources
- None
- Other Sources
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Disease Associations
Cases where the expected disease association was NOT found
Cell color indicative of annotation volume
No data available
Alleles and Variants
Allele/Variant Symbol | Allele Synonyms | Category | Variant | Variant type | Molecular consequence | Has Disease Annotations | Has Phenotype Annotations |
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Transgenic Alleles
Species (carrying the transgene) | Allele symbol | Transgenic construct | Expressed components | Knock-down targets | Regulatory regions | Has Disease Annotations | Has Phenotype Annotations |
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Models
Model name | Experimental condition | Associated Human Diseases | Associated Phenotypes | Modifier | Source |
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Sequence Feature Viewer
- Genome location
- Chr5:148826611...148828623 + (2.01 kb)
- Assembly version
- GRCh38
- Viewer Help
Data currently unavailable; sequence viewer under construction
Expression
- Primary Sources
- None
- Other Sources
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.