Enables transcription corepressor activity. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in cytosol; fibrillar center; and nucleoplasm. Part of transcription repressor complex.
RGD Description
This gene encodes a nuclear protein with three C2H2-type zinc fingers, and functions as a transcriptional repressor. Chromosomal aberrations involving this gene are associated with endometrial stromal tumors. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized [provided by RefSeq, Jul 2008]