Gene

FCHSD2

Species
Homo sapiens
Symbol
FCHSD2
Name
FCH and double SH3 domains 2
Synonyms
  • carom
  • F-BAR and double SH3 domains protein 2
Biotype
protein coding gene
Automated Description
Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in clathrin-dependent endocytosis and positive regulation of Arp2/3 complex-mediated actin nucleation. Located in clathrin-coated pit and plasma membrane.
RGD Description
Enables phosphatidylinositol-3,4,5-trisphosphate binding activity and phosphatidylinositol-3,4-bisphosphate binding activity. Involved in clathrin-dependent endocytosis and positive regulation of Arp2/3 complex-mediated actin nucleation. Located in clathrin-coated pit and plasma membrane. [provided by Alliance of Genome Resources, Nov 2024]
Cross References
Additional Information
Literature

Orthology

Gene tree
PANTHER:PTHR15735
Stringency:
Additional filters to further constrain the results:
Species Gene symbol Count Best Best reverse
Method
Ensembl ComparaHGNCHieranoidInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidXenbaseZFIN
Mus musculusFchsd210 of 10YesYes  
Rattus norvegicusFchsd210 of 10YesYes  
Xenopus tropicalisfchsd28 of 9YesYes   
Danio reriosi:ch211-176g13.89 of 10YesYes  
Drosophila melanogasternwk9 of 9YesYes   
Links to orthology data in JBrowse by filter level: Stringent,  Moderate,  No filter,  Best and Best Reverse

Paralogy

Gene symbolRank Alignment Length (aa) Similarity %Identity %Method Count
Method
Ensembl ComparaHGNCInParanoidOMAOrthoFinderOrthoInspectorPANTHERPhylomeDBSonicParanoidSGD
FCHSD1173956396 of 8  
FNBP1266035212 of 8  
FNBP1L364133202 of 8  
TRIP10458537202 of 8  

Function - GO Annotations

Pathways

No data available

Phenotypes

Primary Sources
None
Other Sources
No data available

Disease Associations

Cases where the expected disease association was NOT found
Must provide at least one subject
Cell color indicative of annotation volume

Alleles and Variants

Genome location
Assembly version
GRCh38
Viewer Help
72.85M72.90M72.95M73.00M73.05M73.10M
Allele/Variant Symbol
Allele Synonyms
Category
Variant
Variant type
Molecular consequence
Has Disease Annotations
Has Phenotype Annotations
NC_000011.10:g.72842718C>Gvariant
SNP
  • missense variant
NC_000011.10:g.72838859G>Cvariant
SNP
  • missense variant
NC_000011.10:g.72887555C>Avariant
SNP
  • missense variant
NC_000011.10:g.72887556A>Cvariant
SNP
  • missense variant
NC_000011.10:g.72867911C>Tvariant
SNP
  • missense variant
NC_000011.10:g.72889839T>Cvariant
SNP
  • missense variant
NC_000011.10:g.73001048T>Cvariant
SNP
  • missense variant
NC_000011.10:g.73001130T>Avariant
SNP
  • missense variant
NC_000011.10:g.72887547C>Tvariant
SNP
  • missense variant
NC_000011.10:g.73001124G>Avariant
SNP
  • missense variant
Showing 1 - 10 of 45 rows
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Transgenic Alleles

No data available

Models

No data available

Sequence Details

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Expression

Primary Sources
None
Other Sources
Must provide at least one subject
Cell color indicative of annotation volume; red slash indicates species lacks structure or developmental stage.

Molecular Interactions

69 interactor genes based on 81 annotations
FCHSD2 molecule type
Interactor gene
Interactor species
Interactor molecule type
Detection methods
Source
Reference
protein
ABCF3Homo sapiens
protein
  • two hybrid
PMID:25416956
protein
ACAP1Homo sapiens
protein
  • two hybrid
PMID:32296183
protein
ANKS1AHomo sapiens
protein
  • two hybrid
PMID:32296183
protein
ATPAF2Homo sapiens
protein
  • two hybrid
PMID:32296183
protein
BORCS6Homo sapiens
protein
  • two hybrid
PMID:32296183
protein
C9orf78Homo sapiens
protein
  • two hybrid
PMID:18654987
protein
CASKHomo sapiens
protein
  • pull down
PMID:14627983
protein
CaskRattus norvegicus
protein
  • pull down
PMID:14627983
protein
CCDC120Homo sapiens
protein
  • two hybrid
PMID:32296183
protein
CCDC158Homo sapiens
protein
  • two hybrid
PMID:16189514
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Genetic Interactions

FCHSD2 role
FCHSD2 genetic perturbation
Interactor gene
Interactor species
Interactor role
Interactor genetic perturbation
Interaction type
Phenotype or trait
Source
Reference
unspecified role
CSKHomo sapiens
unspecified role
synthetic lethality (sensu BioGRID)
  • viability
  • Growth abnormality
PMID:29987050
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